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Index > Protein center > Ccdc109b(Gene name) > Mouse
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  • Ccdc109b (Gene name),
  • Mitochondrial calcium uniporter regulatory subunit MCUb (Protein name ),  MCUB_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ccdc109b(Mcub);
    Protein name:
    Mitochondrial calcium uniporter regulatory subunit MCUb(MCUb);
    Alternative:
    Coiled-coil domain-containing protein 109B;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (By similarity). Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer.
    Function:
    Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
    Subcellular Location:
    Mitochondrion inner membrane Multi-pass membrane protein Mitochondrion
    Protein Attributes:
    Sequence length:
    345
    Sequence:
    50:
    MPGALSGRRM | LPSGLCLGRW | QLLRTIRARG | RGDPRELPST | PQVLCMKLYG | 
    100:
    NPKYHQALHY | GTVEPQDEIT | VTYKHGLPLV | TLTLPSRKER | CQFVVKPMLS | 
    150:
    TVGSFLQDLQ | NEDKGIKTAA | IITADGSEIP | ASTLMDTLLM | TDFKLIINKL | 
    200:
    RYDIRCHKKE | EPSGEHMTEL | ENTKSLVHRL | FTILHLEEIQ | KRRERHLMAK | 
    250:
    IDHLQEQLRP | LEQVKAAIEA | RSEANTSGLL | WAGLALLSVQ | GGALAWLTWW | 
    300:
    VYSWDIMEPV | TFFLSFANSI | VFFAYFIITR | QNYTYSSLRS | RQFLQFFHKK | 
    345:
    SQRRCFDVEQ | YNKLKEDLAE | ATESLESVRR | SLRLRIQGEE | ASEKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MCUb
    Cat.:
    E15447h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse MCUb
    Cat.:
    E15447h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MCUb
    Cat.:
    E15447m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MCUb
    Cat.:
    E15447m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MCUb
    Cat.:
    U15447h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MCUb
    Cat.:
    U15447m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MCUb
    Cat.:
    U15447h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MCUb
    Cat.:
    U15447m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse MCUb
    Cat.:
    P15447Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MCUb
    Cat.:
    P15447Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MCUb
    Cat.:
    P15447Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MCUb
    Cat.:
    P15447Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MCUb
    Monoclonal Antibody for Mouse MCUb
    Monoclonal Antibody for Mouse MCUb
    Monoclonal Antibody for Mouse MCUb
    Protein for Mouse MCUb
    Protein for Mouse MCUb
    Protein for Mouse MCUb
    Protein for Mouse MCUb

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    Precision
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Colon.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit."
      Raffaello A. , De Stefani D. , Sabbadin D. , Teardo E. , Merli G. , Picard A. , Checchetto V. , Moro S. , Szabo I. , Rizzuto R.
      EMBO J.32:2362-2376(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH MCU;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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